Three distinct mechanisms for the activation of secondary B cells to antibody‐forming cells
have been examined in splenic fragment cultures. The clonal response to a protein antigen …

The process by which secondary B cells are generated has intrigued immunologists for
several decades. This is particularly true since appropriate antigenic stimulation leads both …

We have assessed early changes in quiescent B cells Following cognate and bystander
interaction with cloned helper T cells. Variables monitored include Ia expression …

Twenty-five years ago, when I delivered the inaugural lecture of the Scandinavian Society
for Immunology, my mind was filled with germinal centres because of the extraordinary …

The ability to clone hapten-specific B cells in agar and to subsequently trigger their clonal
progeny to antibody synthesis was investigated. Fluorescein (FL) specific B cells were …

In this study it has been investigated whether the interaction of antigen and B cell surface
immunoglobulin (sIg) is required for full clonal expansion of memory B cells specific for the …

This review has summarized the evidence indicating that far more B cells are produced in
adult bone marrow than are required to maintain B cell numbers in the periphery. It is shown …

A subset of B lymphocytes termed “pre-progenitors,” responsible for certain adoptive
immune responses, has previously been defined on the basis of particular physical …

Human T cell clones specific for tetanus toxoid (TT) or for alloantigens were isolated and
expanded in culture using antigen stimulation and soluble growth factors. When stimulated …

Although cognate, MHC-restricted interaction of Th cells with Ag-presenting B cells provides
effective help to a resting B cell, substantial B cell responses have also been seen with …