Target discovery is one of the essential steps in modern drug development, and the
identification of promising targets is fundamental for developing first-in-class drug. A variety …

Abstract Knowledge and investigation of therapeutic targets (responsible for drug efficacy)
and the targeted drugs facilitate target and drug discovery and validation. Therapeutic …

Increasing numbers of proteins, nucleic acids and other molecular entities have been
explored as therapeutic targets, hundreds of which are targets of approved and clinical trial …

Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

The drug discovery process typically involves target identification and design of suitable
drug molecules against these targets. Despite decades of experimental investigations in the …

Highlights•Compound target ID technologies have unique strengths that can be used
strategically.•Target ID approaches are trending toward unbiased, genome-wide …

Extensive efforts have been directed at the discovery, investigation and clinical monitoring of
targeted therapeutics. These efforts may be facilitated by the convenient access of the …

Extensive drug discovery efforts have yielded many approved and candidate drugs targeting
various targets in different biological pathways. Several freely accessible databases provide …

The largest innovations within pharmaceutical development come through new compounds
that have unique and novel modes of action. These innovations commonly involve …

The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12
years and is estimated to cost upwards of US $800 million for each drug to be successfully …