A century ago, Otto Heinrich Warburg made a seminal discovery now known as the Warburg
effect. This metabolic signature, prevalent across all cancer cells, is characterized by the …

Abstract" To be, or not to be?" This question is not only Hamlet's agony but also the dilemma
of mitochondria in a cancer cell. Cancer cells have a high glycolysis rate even in the …

Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …

Cancer cells reprogram their energy metabolic system from the mitochondrial oxidative
phosphorylation (OXPHOS) pathway to a glucose-dependent aerobic glycolysis pathway …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

The precise mitochondrial alterations that underlie the increased dependence of cancer
cells on aerobic glycolysis for energy generation have remained a mystery. Recent evidence …

The Warburg effect was first described by Otto Warburg in the 1920s and describes the
preferential conversion of glucose to lactate as opposed to its metabolism through the citric …

A defining hallmark of tumor phenotypes is uncontrolled cell proliferation, while fermentative
glycolysis has long been considered as one of the major metabolic pathways that allows …

This review focuses on the evolving understanding that we have of tumor cell metabolism,
particularly glycolytic and oxidative metabolism, and traces back its evolution through time …