Phenomapping in heart failure with preserved ejection fraction: insights, limitations, and future directions

AE Peters, J Tromp, SJ Shah, CSP Lam… - Cardiovascular …, 2022 - academic.oup.com
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous entity with
complex pathophysiology and manifestations. Phenomapping is the process of applying …

Phenomapping for novel classification of heart failure with preserved ejection fraction

SJ Shah, DH Katz, S Selvaraj, MA Burke, CW Yancy… - Circulation, 2015 - Am Heart Assoc
Background—Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous
clinical syndrome in need of improved phenotypic classification. We sought to evaluate …

Research priorities for heart failure with preserved ejection fraction: national heart, lung, and blood institute working group summary

SJ Shah, BA Borlaug, DW Kitzman, AD McCulloch… - Circulation, 2020 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF), a major public health problem that is
rising in prevalence, is associated with high morbidity and mortality and is considered to be …

Biological phenotypes of heart failure with preserved ejection fraction

GA Lewis, EB Schelbert, SG Williams… - Journal of the American …, 2017 - jacc.org
Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological
mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and …

[HTML][HTML] Biomarkers in heart failure with preserved ejection fraction

A Bayes-Genis, G Cediel, M Domingo… - Cardiac Failure …, 2022 - ncbi.nlm.nih.gov
Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder
developing from multiple aetiologies with overlapping pathophysiological mechanisms …

Murine models of heart failure with preserved ejection fraction: a “fishing expedition”

M Valero-Muñoz, W Backman, F Sam - Basic to Translational Science, 2017 - jacc.org
Heart failure with preserved ejection fraction (HFpEF) is characterized by signs and
symptoms of heart failure in the presence of a normal left ventricular ejection fraction …

Treatment of heart failure with preserved ejection fraction (HFpEF): the phenotype-guided approach

DN Silverman, SJ Shah - Current treatment options in cardiovascular …, 2019 - Springer
The syndrome of heart failure with preserved ejection (HFpEF) continues to rise in
prevalence without persuasive evidence of current pharmacologic interventions that can …

Heart failure with preserved ejection fraction: controversies, challenges and future directions

R Zakeri, MR Cowie - Heart, 2018 - heart.bmj.com
Heart failure with preserved ejection fraction (HFpEF) comprises almost half of the
population burden of HF. Because HFpEF likely includes a range of cardiac and non-cardiac …

Phenotype-specific treatment of heart failure with preserved ejection fraction: a multiorgan roadmap

SJ Shah, DW Kitzman, BA Borlaug, L Van Heerebeek… - Circulation, 2016 - Am Heart Assoc
Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF
cases, and its prevalence relative to HF with reduced EF continues to rise. In contrast to HF …

Heart failure with preserved ejection fraction: heterogeneous syndrome, diverse preclinical models

J Roh, JA Hill, A Singh, M Valero-Muñoz… - Circulation …, 2022 - Am Heart Assoc
Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …