Abstract P‐glycoprotein (P‐gp) is an efflux transporter at the blood–brain barrier (BBB) that
hinders brain access of substrate drugs and clears endogenous molecules such as amyloid …

P-glycoprotein (P-gp), expressed at the blood-brain barrier (BBB), is critical in preventing
brain access to substrate drugs and effluxing amyloid beta (Aβ), a contributor to Alzheimer's …

Purpose P-glycoprotein (P-gp) at the blood-brain barrier (BBB) precludes the brain
penetration of many xenobiotics and mediates brain-to-blood clearance of β-amyloid, which …

Purpose Biometals such as zinc and copper have been shown to affect tight junction
expression and subsequently blood-brain barrier (BBB) integrity. Whether these biometals …

Developing new therapies for stroke is urgently needed, as this disease is the leading cause
of death and disability worldwide, and the existing treatment is only available for a small …

Alzheimer's disease (AD) is the most prevalent cause of dementia characterized by a
progressive cognitive decline. Addressing neuroinflammation represents a promising …

The molecular basis of Alzheimer's disease has not been clearly established, but disruption
of brain metal ion homeostasis, particularly copper and zinc, might be closely involved in the …

Neuroinflammation has a major role in several brain disorders including Alzheimer's
disease (AD), yet at present there are no effective anti-neuroinflammatory therapeutics …

Previous studies have demonstrated that the ionophore clioquinol (CQ), in conjunction with
the biometals copper and zinc, increases the expression of P-glycoprotein (P-gp) in human …

Background: Neuroinflammation and biometal dyshomeostasis are key pathological
features of several neurodegenerative diseases, including Alzheimer's disease (AD) …