[HTML][HTML] SARS-CoV-2-specific T cells associate with inflammation and reduced lung function in pulmonary post-acute sequalae of SARS-CoV-2

KM Littlefield, RO Watson, JM Schneider… - PLoS …, 2022 - journals.plos.org
As of January 2022, at least 60 million individuals are estimated to develop post-acute
sequelae of SARS-CoV-2 (PASC) after infection with severe acute respiratory syndrome …

[PDF][PDF] Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19

J Neidleman, X Luo, AF George, M McGregor, J Yang… - Cell Reports, 2021 - cell.com
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …

[PDF][PDF] Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms

MJ Peluso, AN Deitchman, L Torres, NS Iyer… - Cell Reports, 2021 - cell.com
We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell
responses, soluble markers of inflammation, and antibody levels and neutralization capacity …

Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19

N Kaneko, J Boucau, HH Kuo, C Perugino… - Clinical …, 2022 - Elsevier
Many studies have been performed in severe COVID-19 on immune cells in the circulation
and on cells obtained by bronchoalveolar lavage. Most studies have tended to provide …

Phenotype and kinetics of SARS-CoV-2–specific T cells in COVID-19 patients with acute respiratory distress syndrome

D Weiskopf, KS Schmitz, MP Raadsen, A Grifoni… - Science …, 2020 - science.org
SARS-CoV-2 has been identified as the causative agent of a global outbreak of respiratory
tract disease (COVID-19). In some patients, the infection results in moderate to severe acute …

[HTML][HTML] COVID-19-induced ARDS is associated with decreased frequency of activated memory/effector T cells expressing CD11a++

M Anft, K Paniskaki, A Blazquez-Navarro, A Doevelaar… - Molecular Therapy, 2020 - cell.com
Preventing the progression to acute respiratory distress syndrome (ARDS) in COVID-19 is
an unsolved challenge. The involvement of T cell immunity in this exacerbation remains …

[PDF][PDF] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals

A Grifoni, D Weiskopf, SI Ramirez, J Mateus, JM Dan… - Cell, 2020 - cell.com
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …

[HTML][HTML] High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

D Schub, V Klemis, S Schneitler, J Mihm, PM Lepper… - JCI insight, 2020 - ncbi.nlm.nih.gov
BACKGROUND Patients infected with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) differ in the severity of disease. We hypothesized that characteristics of SARS …

[PDF][PDF] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

PA Szabo, P Dogra, JI Gray, SB Wells, TJ Connors… - Immunity, 2021 - cell.com
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …

Differential redistribution of activated monocyte and dendritic cell subsets to the lung associates with severity of COVID-19

I Sanchez-Cerrillo, P Landete, B Aldave… - MedRxiv, 2020 - medrxiv.org
The SARS-CoV-2 is responsible for the pandemic COVID-19 in infected individuals, who
can either exhibit mild symptoms or progress towards a life-threatening acute respiratory …