Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing

L Wittner, L Wagener, JJ Wiese, I Stolzer… - International journal of …, 2023 - mdpi.com
The paracaspase MALT1 is a crucial regulator of immune responses in various cellular
contexts. Recently, there is increasing evidence suggesting that MALT1 might represent a …

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation

F Bornancin, F Renner, R Touil, H Sic… - The Journal of …, 2015 - journals.aai.org
The paracaspase MALT1 plays an important role in immune receptor-driven signaling
pathways leading to NF-κB activation. MALT1 promotes signaling by acting as a scaffold …

[PDF][PDF] A two-step activation mechanism of MALT1 paracaspase

J Staal, R Beyaert - Journal of Molecular Biology, 2012 - biblio.ugent.be
The paracaspase MALT1 plays a central signaling role in the response to activation of a
growing list of receptors found on immune cells and other cell types. However, the best …

Probes to monitor activity of the paracaspase MALT1

J Hachmann, LE Edgington-Mitchell, M Poreba… - Chemistry & biology, 2015 - cell.com
The human paracaspase mucosa-associated lymphoid tissue lymphoma translocation
protein 1 (MALT1) plays a central role in nuclear factor-κB (NF-κB) signaling as both a …

Monoubiquitination and activity of the paracaspase MALT1 requires glutamate 549 in the dimerization interface

K Cabalzar, C Pelzer, A Wolf, G Lenz, J Iwaszkiewicz… - PloS one, 2013 - journals.plos.org
The mucosa-associated lymphoid tissue protein-1 (MALT1, also known as paracaspase) is a
protease whose activity is essential for the activation of lymphocytes and the growth of cells …

Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation

A Gewies, O Gorka, H Bergmann, K Pechloff… - Cell reports, 2014 - cell.com
The paracaspase Malt1 is a central regulator of antigen receptor signaling that is frequently
mutated in human lymphoma. As a scaffold, it assembles protein complexes for NF-κB …

[HTML][HTML] Malt1 protease deficiency in mice disrupts immune homeostasis at environmental barriers and drives systemic T cell–mediated autoimmunity

K Martin, R Touil, Y Kolb, G Cvijetic… - The Journal of …, 2019 - journals.aai.org
The paracaspase Malt1 is a key regulator of canonical NF-κB activation downstream of
multiple receptors in both immune and nonimmune cells. Genetic disruption of Malt1 …

MALT 1 protease: equilibrating immunity versus tolerance

A Bertossi, D Krappmann - The EMBO Journal, 2014 - embopress.org
MALT 1 paracaspase links signaling cascades emanating from adaptive or innate immune
receptors to the canonical NF‐κB pathway. Now, Jaworski et al (2014) investigate the …

MALT1 protease activity is required for innate and adaptive immune responses

JW Yu, S Hoffman, AM Beal, A Dykon, MA Ringenberg… - PloS one, 2015 - journals.plos.org
CARMA-BCL10-MALT1 signalosomes play important roles in antigen receptor signaling and
other pathways. Previous studies have suggested that as part of this complex, MALT1 …

Malt1 protease is critical in maintaining function of regulatory T cells and may be a therapeutic target for antitumor immunity

L Cheng, N Deng, N Yang, X Zhao… - The Journal of …, 2019 - journals.aai.org
The paracaspase Malt1 is a key molecule in mediating Ag receptor–induced NF-κB
activation in lymphocytes, but the role of Malt1 in the function of regulatory T (Treg) cells is …