Novel role of COX6c in the regulation of oxidative phosphorylation and diseases

C Wang, J Lv, C Xue, J Li, Y Liu, D Xu, Y Jiang… - Cell death …, 2022 - nature.com
Cytochrome c oxidase subunit VIc (COX6c) is one of the most important subunits of the
terminal enzyme of the respiratory chain in mitochondria. Numerous studies have …

[HTML][HTML] Differential expression and clinical significance of COX6C in human diseases

BX Tian, W Sun, SH Wang, PJ Liu… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Mitochondria, independent double-membrane organelles, are intracellular power plants that
feed most eukaryotic cells with the ATP produced via the oxidative phosphorylation …

COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism

Y Feng, J Xu, M Shi, R Liu, L Zhao, X Chen, M Li… - Cell death & …, 2022 - nature.com
COX7A1, a subunit of cytochrome c oxidase, holds an important position in the super-
assembly which integrates into multi-unit heteromeric complexes peripherally in the …

COX7AR is a stress-inducible mitochondrial COX subunit that promotes breast cancer malignancy

K Zhang, G Wang, X Zhang, PP Hüttemann, Y Qiu… - Scientific Reports, 2016 - nature.com
Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain,
plays a key role in regulating mitochondrial energy production and cell survival. COX …

Downregulation of cytochrome c oxidase subunit 7A1 expression is important in enhancing cell proliferation in adenocarcinoma cells

N Mishra, U Timilsina, D Ghimire, RC Dubey… - … and biophysical research …, 2017 - Elsevier
Mitochondrial Dysfunction has been implicated in multiple human diseases, including
cancer. Among all cancer, lung cancer is the most common type of cancer worldwide with …

[HTML][HTML] Overexpression of COX7RP promotes tumor growth and metastasis by inducing ROS production in hepatocellular carcinoma cells

G Wang, B Popovic, J Tao, A Jiang - American Journal of Cancer …, 2020 - ncbi.nlm.nih.gov
Cumulative evidence has indicated that mitochondrial respiration dysfunction plays
important roles in tumorigenesis. However, the role of COX7RP, a critical regulator in the …

Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency

L Douiev, C Miller, S Ruppo, H Benyamini… - Cells, 2021 - mdpi.com
Cytochrome-c-oxidase (COX) subunit 4 (COX4) plays important roles in the function,
assembly and regulation of COX (mitochondrial respiratory complex 4), the terminal electron …

[HTML][HTML] Loss of COX5B inhibits proliferation and promotes senescence via mitochondrial dysfunction in breast cancer

SP Gao, HF Sun, HL Jiang, LD Li, X Hu, XE Xu, W Jin - Oncotarget, 2015 - ncbi.nlm.nih.gov
COX5B, a peripheral subunit of the cytochrome c oxidase complex, has previously been
reported to maintain the stability of this complex. However, its functions and mechanisms …

COX7A1 suppresses the viability of human non‐small cell lung cancer cells via regulating autophagy

L Zhao, X Chen, Y Feng, G Wang, I Nawaz… - Cancer …, 2019 - Wiley Online Library
COX7A1 is a subunit of cytochrome c oxidase, and plays an important role in the super‐
assembly that integrates peripherally into multi‐unit heteromeric complexes in the …

APOPT 1/COA 8 assists COX assembly and is oppositely regulated by UPS and ROS

A Signes, R Cerutti, AS Dickson, C Benincá… - EMBO molecular …, 2019 - embopress.org
Loss‐of‐function mutations in APOPT 1, a gene exclusively found in higher eukaryotes,
cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial …