Background The time stratified case cross-over approach is a popular alternative to
conventional time series regression for analysing associations between time series of …

The case-crossover design was introduced in epidemiology 15 years ago as a method for
studying the effects of a risk factor on a health event using only cases. The idea is to …

The case‐crossover design uses cases only, and compares exposures just prior to the event
times to exposures at comparable control, or 'referent'times, in order to assess the effect of …

Background Time series analysis is the most commonly used technique for assessing the
association between counts of health events over time and exposure to ambient air …

We are living in a changing environment that affects human health. It is vital to use proper
methods to quantify the impact of environmental exposure (eg, air pollutants and extreme …

The case-crossover design was developed to study the effects of transient, short-term
exposures on the risk of acute events, such as myocardial infarction, in the early 1990s. This …

The case-crossover study design is a popular analytic tool for estimating the effects of
triggers of acute outcomes by environmental exposures. Although this approach controls for …

Selection bias due to loss to follow up represents a threat to the internal validity of estimates
derived from cohort studies. Over the past 15 years, stratification-based techniques as well …

The case–crossover design has been widely used to study the association between short-
term air pollution exposure and the risk of an acute adverse health event. The design uses …

Modified Poisson regression, which combines a log Poisson regression model with robust
variance estimation, is a useful alternative to log binomial regression for estimating relative …