The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-
E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating …

The E2F family of transcription factors is a central modulator of important cellular events,
including cell cycle progression, apoptosis and DNA damage response. The role of E2F …

Abstract E2F transcription factor 1 (E2F1) is a member of the E2F family of transcription
factors. E2F1 binds to DNA with dimerization partner (DP) proteins through an E2 …

E2F-1 is an intriguing transcription factor that accumulates the integrated signal of the G1-S
transition regulators. Its role in cell fate, as depicted from in vivo models and a few studies on …

The E2F family of transcription factors plays a pivotal role in the regulation of cell
proliferation and their activity is often deregulated in human tumors. Recent studies …

Background: The retinoblastoma (Rb) pathway, which governs cell cycle progression, is
frequently genetically altered in cancer, causing deregulated expression of the E2F-1 …

The E2F family of transcription factors consists of nine members with both distinct and
overlapping functions. These factors are situated downstream of growth factor signaling …

Progression through the cell cycle is dependent upon the temporal and spatial regulation of
the various members of the E2F family of transcription factors. Two of these members, E2F1 …

Mutation or inactivation of the retinoblastoma (Rb) tumor suppressor occurs inmost human
tumors and results in the deregulation of several members of the E2F familyof transcription …

The E2F transcription factor family plays a crucial and well established role in cell cycle
progression. Deregulation of E2F activities in vivo leads to developmental defects and …