Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF …

YJ Surh, KS Chun, HH Cha, SS Han, YS Keum… - Mutation Research …, 2001 - Elsevier
A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review

YJ Surh - Food and Chemical Toxicology, 2002 - Elsevier
A wide variety of phenolic substances derived from spice possess potent antimutagenic and
anticarcinogenic activities. Examples are curcumin, a yellow colouring agent, contained in …

Targeting NOX, INOS and COX‐2 in inflammatory cells: chemoprevention using food phytochemicals

A Murakami, H Ohigashi - International journal of cancer, 2007 - Wiley Online Library
Biological, biochemical and physical stimuli activate inflammatory leukocytes, such as
macrophages, resulting in induction and synthesis of proinflammatory proteins and …

Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals

JK Kundu, YJ Surh - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
Center to the cancer biology is disrupted intracellular signaling network, which transmits
improper signals resulting in abnormal cellular functioning. Therefore, modulation of …

Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

A Salminen, M Lehtonen, T Suuronen… - Cellular and Molecular …, 2008 - Springer
Traditional medicine has been a fertile source for revealing novel lead molecules for modern
drug discovery. In plants, terpenoids represent a chemical defense against environmental …

Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-κB activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine …

PS Son, SA Park, HK Na, DM Jue, S Kim… - …, 2010 - academic.oup.com
There are multiple lines of evidence supporting that chronic inflammation is linked to
carcinogenesis. Nuclear factor-κB (NF-κB), a major redox-sensitive transcription factor …

Prevention of human cancer by modulation of chronic inflammatory processes

H Ohshima, H Tazawa, BS Sylla, T Sawa - Mutation Research/Fundamental …, 2005 - Elsevier
Chronic inflammation induced by biological, chemical and physical factors has been
associated with increased risk of human cancer at various sites. Inflammation facilitates the …

Targeting specific cell signaling transduction pathways by dietary and medicinal phytochemicals in cancer chemoprevention

VS Neergheen, T Bahorun, EW Taylor, LS Jen… - Toxicology, 2010 - Elsevier
Natural phytochemicals derived from dietary sources or medicinal plants have gained
significant recognition in the potential management of several human clinical conditions …

Molecular basis of the anti-inflammatory effects of terpenoids

S Hortelano - Inflammation & Allergy-Drug Targets (Formerly …, 2009 - ingentaconnect.com
Natural products play a significant role in human health in relation to the prevention and
treatment of inflammatory conditions. Among them, terpenoids (also referred to as terpenes) …

NF-κB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals

YJ Surh, HK Na - Genes & nutrition, 2008 - Springer
Cancer is a multifactorial heterogeneous disease characterized by multistage nature of
pathogenesis. Over the past two or three decades, we have witnessed an enormous …