The intricate shaping of the facial skeleton is essential for function of the vertebrate jaw and
middle ear. While much has been learned about the signaling pathways and transcription …

Patterning of the facial skeleton involves the precise deployment of thousands of genes in
distinct regions of the pharyngeal arches. Despite the significance for craniofacial …

A conserved endothelin 1 signaling pathway patterns the jaw and other pharyngeal skeletal
elements in mice, chicks and zebrafish. In zebrafish, endothelin 1 (edn1 or sucker) is …

Patterning of the upper versus lower face involves generating distinct pre-skeletal identities
along the dorsoventral (DV) axes of the pharyngeal arches. Whereas previous studies have …

Patterning of the vertebrate facial skeleton involves the progressive partitioning of neural-
crest-derived skeletal precursors into distinct subpopulations along the anteroposterior (AP) …

Endothelin-1 (Edn1) signaling provides a critical input to development of the embryonic
pharygneal arches and their skeletal derivatives, particularly the articulating joints and the …

Bone morphogenetic proteins (BMPs) play crucial roles in craniofacial development but little
is known about their interactions with other signals, such as Endothelin 1 (Edn1) and …

The ventrally expressed secreted polypeptide endothelin1 (Edn1) patterns the skeleton
derived from the first two pharyngeal arches into dorsal, intermediate and ventral domains …

Forward genetic analyses can reveal important developmental regulatory genes and how
they function to pattern morphology. This is because a mutated gene can produce a novel …

The zebrafish has emerged as an important model for vertebrate development as it relates to
human health and disease. Work in this system has provided significant insights into the …