Protein− nucleic acid interactions, including the interac-tions of proteins with DNA, RNA, and
DNA/RNA hybrid, often confer important biological consequences to targeted nucleic acids …

The identification of the regulatory proteins that control DNA transcription as well as RNA
stability and translation represents a key step in the comprehension of gene expression …

Nearly 10 years ago, Ganem et al. published a seminal work demonstrating that a
noncovalent complex between FK binding protein (Mw 11 812 Da) and the ligand FK506 …

Mass spectrometry (MS)-based quantitative interaction proteomics has successfully
elucidated specific protein–protein, DNA–protein, and small molecule–protein interactions …

The fields of application of functional proteomics are not limited to the study of protein–
protein interactions; they also extend to those involving protein complexes that bind DNA or …

In recent years, quantitative mass spectrometry-based interaction proteomics technology
has proven very useful in identifying specific DNA–protein interactions using single pull …

Interaction proteomics studies have provided fundamental insights into multimeric
biomolecular assemblies and cell-scale molecular networks. Significant recent …

Mass spectrometry is currently at the forefront of technologies for mapping protein–protein
interactions, as it is a highly sensitive technique that enables the rapid identification of …

Vital cellular processes including genome replication, transcription, translation, and repair
rely on specific interactions between proteins and nucleic acids to complete diverse and …

Abstract I. Introduction 306 II. Supramolecular Structure Characterization 308 A. A Protein Is
Used as a “Hook” 309 1. Immuno‐Precipitation 309 2. Tagging with a Poly‐Histidine …