Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

T cell-mediated inflammatory immune responses contribute to both the clearance and
pathology of malaria infections; the host's ability to down-regulate inflammation once …

Malaria is a major global health problem. Despite decades of research, there is still no
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been
used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria …

An effective immune response to infection requires control of pathogen growth while
minimizing inflammation-associated pathology. During malaria infection, this balance is …

The inability to acquire protective immunity against Plasmodia is the chief obstacle to
malaria control, and inadequate T-cell responses may facilitate persistent blood-stage …

It is thought that both helper and effector functions of CD4+ T cells contribute to protective
immunity to blood stage malaria infection. However, malaria infection does not induce long …

The optimal outcome of a malaria infection is that parasitized cells are killed and degraded
without inducing significant pathology. Since much of the pathology of malaria infection can …

T cells are important in the immune response to malaria, both for their cytokines and their
help for antibody production. To look at the relative importance of these roles, a T-cell …

Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect
hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria …