Rationale Impulsive aggressive personality disordered patients have been shown to have
decreased relative glucose metabolism in orbito-frontal cortex and anterior cingulate gyrus …

Prefrontal hypoperfusion and decreased glucose uptake in the prefrontal cortex (PFC) are
found in violent criminal offenders, murderers and aggressive psychiatric patients. These …

Background Impulsive aggression is a prevalent problem and yet little is known about its
neurobiology. Preclinical and human studies suggest that the orbital frontal cortex and …

Reduced serotonergic activity has been associated with impulsive aggression in personality
disordered patients in metabolite and pharmacologic challenge studies. This study used …

Abnormal fronto-amygdala circuitry has been implicated in impulsive aggression, a core
symptom of borderline personality disorder (BPD). We examined relative glucose metabolic …

Background: Impulsive aggression in patients with personality disorders is associated with
diminished levels of cerebrospinal fluid (CSF) 5-HIAA, blunted neuroendocrine responses to …

BACKGROUND: Borderline personality disorder (BPD) is often associated with symptoms of
impulsive aggression, which poses a threat to patients themselves and to others. Preclinical …

Neuroimaging studies of impulsive–aggressive subjects with borderline personality disorder
(BPD) demonstrate hypometabolism in areas of prefrontal and frontal cortex, and a blunted …

Background. Reduced serotonin (5-HT) function and deficits on neuropsychological tasks
have been separately reported in antisocial populations. We investigated whether these …

Previous neuroimaging studies of major depression have not controlled for the presence of
personality disorders characterized by impulsive aggressive behavior, such as borderline …