The methionine addiction of cancer cells is known as the Hoffman effect. While non-cancer
cells in culture can utilize homocysteine in place of methionine for cellular growth, most …

Methionine addiction is a fundamental and general hallmark of cancer and is an area of
current intense interest. Methionine addiction results from the overuse of methionine by …

Methionine addiction, found in all types of cancer investigated, is because of the overuse of
methionine by cancer cells for excess transmethylation reactions. In the present study, we …

Methionine addiction is a fundamental and general hallmark of cancer. Methionine addiction
prevents cancer cells, but not normal cells from proliferation under methionine restriction …

Background/Aim: Methionine addiction, a fundamental and general hallmark of cancer, is
due to the excess use of methionine for transmethylation, and is described as the Hoffman …

Methionine addiction, a fundamental and general hallmark of cancer, known as the Hoffman
Effect, is due to altered use of methionine for increased and aberrant transmethylation …

Methionine addiction is a fundamental and general hallmark of cancer cells, which require
exogenous methionine, despite their ability to synthesize normal amounts of methionine …

Many different types of cancer cells have been shown to be methionine (MET) dependent.
Cancer cells, unlike normal cells, grow poorly or not at all when MET is restricted. Cancer …

Methionine addiction is a fundamental and general hallmark of cancer. Methionine addiction
results from the overuse of methionine by cancer cells for excess transmethylation reactions …

Abstract Background/Aim: The fundamental and general hallmark of cancer cells,
methionine addiction, termed the Hoffman effect, is due to overuse of methionine for highly …