Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Of all the proposed causes of ageing, DNA damage remains a leading, though still debated
theory. Unlike most other types of age-related cellular damage, which can hypothetically be …

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …

Aging is a multifaceted process characterized by genetic and epigenetic changes in the
genome. The genetic component of aging received initially all of the attention. Telomere …

Genome modifications resulting from epigenetic changes appear to play a critical role in the
development and/or progression of cancer. Scatter experimental evidence suggests that …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

The term epigenetics refers to stable patterns of gene expression that are seen during
differentiation or X chromosome inactivation and are not dependent on dynamic changes in …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

DNA damage-driven genome instability underlies the diversity of life forms generated by the
evolutionary process but is detrimental to the somatic cells of individual organisms. The …