Alzheimer's disease

P Scheltens, B De Strooper, M Kivipelto, H Holstege… - The Lancet, 2021 - thelancet.com
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Alzheimer's disease: clinical trials and drug development

F Mangialasche, A Solomon, B Winblad… - The Lancet …, 2010 - thelancet.com
Alzheimer's disease is the most common cause of dementia in elderly people. Research into
Alzheimer's disease therapy has been at least partly successful in terms of developing …

Alzheimer's disease

P Scheltens, K Blennow, MMB Breteler, B De Strooper… - The Lancet, 2016 - thelancet.com
Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

Why do so many clinical trials of therapies for Alzheimer's disease fail?

RM Anderson, C Hadjichrysanthou, S Evans… - The Lancet, 2017 - thelancet.com
Alzheimer's disease is an irreversible, progressive brain disorder that accounts for about 50–
75% of all cases of dementia. 1 Alzheimer's disease is characterised by the presence of …

Alzheimer's disease

C Ballard, S Gauthier, A Corbett, C Brayne, D Aarsland… - the Lancet, 2011 - thelancet.com
An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …

Advances in Alzheimer's disease research over the past two decades

CR Jack - The Lancet Neurology, 2022 - thelancet.com
Over the past two decades, the landscape of dementia research has changed drastically
due to advances in knowledge at the molecular, cellular, animal, and human levels …

Alzheimer's disease

K Blennow, MJ de Leon, H Zetterberg - The Lancet, 2006 - thelancet.com
Alzheimer's disease is the most common cause of dementia. Research advances have
enabled detailed understanding of the molecular pathogenesis of the hallmarks of the …

Making Alzheimer's and dementia research fit for populations

C Brayne, D Davis - The Lancet, 2012 - thelancet.com
Two decades ago, the established view was that ageing and Alzheimer's disease arise from
distinct pathophysiological processes. Tremendous scientific efforts were underway to …

Potential for primary prevention of Alzheimer's disease: an analysis of population-based data

S Norton, FE Matthews, DE Barnes, K Yaffe… - The Lancet …, 2014 - thelancet.com
Background Recent estimates suggesting that over half of Alzheimer's disease burden
worldwide might be attributed to potentially modifiable risk factors do not take into account …

Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project

CW Ritchie, JL Molinuevo, L Truyen, A Satlin… - The Lancet …, 2016 - thelancet.com
Alzheimer's dementia affects more than 40 million people worldwide with substantial
increases in prevalence anticipated. Interventions that either modify risk or reduce the …