Replication of eukaryotic positive-stranded RNA viruses is usually linked to the presence of
membrane-associated replicative organelles. The purpose of this review is to discuss the …

The replication of coronaviruses, as in other positive-strand RNA viruses, is closely tied to
the formation of membrane-bound replicative organelles inside infected cells. The proteins …

Coronaviruses are positive-strand RNA viruses that are important infectious agents of both
animals and humans. A common feature among positive-strand RNA viruses is their …

If we use the analogy of a virus as a living entity, then the replicative organelle is the part of
the body where its metabolic and reproductive activities are concentrated. Recent studies …

Coronaviruses express two very large replicase polyproteins, the 16 autoproteolytic
cleavage products of which collectively form the membrane-anchored replication …

The coronavirus nucleocapsid (N) protein is a virion structural protein. It also functions,
however, in an unknown way in viral replication and localizes to the viral replication …

Coronavirus genome replication is mediated by a multi-subunit protein complex that is
comprised of more than a dozen virally encoded and several cellular proteins. Interactions of …

Coronaviruses encode large replicase polyproteins which are proteolytically processed by
viral proteases to generate mature nonstructural proteins (nsps) that form the viral replication …

The coronavirus nonstructural proteins (nsp's) derived from the replicase polyproteins
collectively constitute the viral replication complexes, which are anchored to double …

This chapter reviews the processing, targeting, and assembly of the coronavirus structural
proteins, and the release of assembled virions from infected cells. Both virus‐like particles …