Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Developments of many renal diseases are substantially influenced by epigenetic
modifications of numerous genes, mainly mediated by DNA methylations, histone …

Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

Klotho in health and disease : Current Opinion in Nephrology and Hypertension Klotho in
health and disease : Current Opinion in Nephrology and Hypertension Log in or Register …

Chronic kidney disease (CKD) is an inherently systemic disease that refers to a long-term
loss of kidney function. The progression of CKD has repercussions for other organs, leading …

Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

Klotho is highly expressed in the kidney and a soluble form of Klotho functions as an
endocrine substance that exerts multiple actions including the modulation of renal solute …

The extracellular domain of transmembrane alpha-Klotho (αKlotho, hereinafter simply called
Klotho) is cleaved by secretases and released into the circulation as soluble Klotho. Soluble …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Background Klotho gene was identified as an aging suppressor. In animals, klotho
overexpression extends life span, and defective klotho results in rapid aging and early …