To evaluate the risk of a disease associated with the joint effects of genetic susceptibility and
environmental exposures, epidemiologic researchers often test for non-multiplicative gene …

To evaluate the risk of a disease associated with the joint effects of genetic susceptibility and
environmental exposures, epidemiologic researchers often test for non‐multiplicative gene …

Several methods for screening gene-environment interaction have recently been proposed
that address the issue of using gene-environment independence in a data-adaptive way. In …

The conventional method of detecting gene-environment interactions, the case-control
analysis, suffers from low statistical power. In contrast, the case-only analysis/design can be …

Background The case-only study for investigating gene–environment interactions provides
increased statistical efficiency over case-control analyses. This design has been criticized …

To increase the power and efficiency in case-control studies exploring gene-environment
interaction, Stürmer and Brenner advocated “flexible matching strategies”(1, pp. 600–601) …

Novel epidemiologic study designs are often required to assess gene-environment
interaction. A design using only cases, without controls, is one of several approaches that …

For analysis of case-control genetic association studies, it has recently been shown that
gene-environment independence in the population can be leveraged to increase efficiency …

Assuming continuous, normally distributed environmental and categorical genotype
variables, the authors compare 6 case-only designs for tests of association in gene …

In this article, the authors propose to simultaneously test for marginal genetic association
and gene-environment interaction to discover single nucleotide polymorphisms that may be …