Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria-dependent pathways

M Li, T Kondo, QL Zhao, FJ Li, K Tanabe, Y Arai… - Journal of Biological …, 2000 - ASBMB
Apoptosis induced by cadmium has been shown in many tissues in vivo and in cultured cells
in vitro. However, its molecular mechanism is not fully understood. When the human …

Cadmium induces caspase-mediated cell death: suppression by Bcl-2

MS Kim, BJ Kim, HN Woo, KW Kim, KB Kim, IK Kim… - Toxicology, 2000 - Elsevier
Apoptosis is a process of active cell death and is characterized by activation of caspases,
DNA fragmentation, and biochemical and morphological changes. To better understand …

Cadmium induces apoptotic cell death in WI 38 cells via caspase-dependent Bid cleavage and calpain-mediated mitochondrial Bax cleavage by Bcl-2-independent …

SH Oh, BH Lee, SC Lim - Biochemical pharmacology, 2004 - Elsevier
Previous reports have demonstrated that cadmium (Cd) may induce cell death via apoptosis,
but the mechanism responsible for cellular death is not clear. In this study, we investigated …

Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells

M Kondoh, S Araragi, K Sato, M Higashimoto… - Toxicology, 2002 - Elsevier
Cadmium (Cd), a potent immunotoxic metal, induces apoptosis both in vitro and in vivo.
However, the mode of action remains unclear. We previously reported that Cd-induced …

Cadmium-induced apoptosis in C6 glioma cells: mediation by caspase 9-activation

W Wätjen, M Cox, M Biagioli, D Beyersmann - Biometals, 2002 - Springer
The induction of apoptotic cell death by cadmium was investigated in eight mammalian cell
lines. Great differences in the cytotoxicity of cadmium were found with different cell lines: Rat …

Mitochondria‐mediated caspase‐independent apoptosis induced by cadmium in normal human lung cells

CM Shih, JS Wu, WC Ko, LF Wang… - Journal of Cellular …, 2003 - Wiley Online Library
Cadmium, a well‐known environmental hazard, has caused serious health problems in
humans and animals. Accumulating evidence suggests the cadmium toxicity is mediated by …

Cadmium Induces Ca2+-Dependent Necrotic Cell Death through Calpain-Triggered Mitochondrial Depolarization and Reactive Oxygen Species-Mediated Inhibition …

PM Yang, HC Chen, JS Tsai, LY Lin - Chemical Research in …, 2007 - ACS Publications
This study investigates the mechanism of cell death induced by cadmium (Cd) in Chinese
hamster ovary (CHO) cells. Cells exposed to 4 μM Cd for 24 h did not show signs of …

Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and …

A Lemarié, D Lagadic-Gossmann, C Morzadec… - Free Radical Biology …, 2004 - Elsevier
Cadmium-induced cellular toxicity has been related to necrosis and/or caspase-dependent
apoptosis. In the present study, we show that, on cadmium exposure, the human …

Mechanism of cadmium induced apoptosis in the immunocyte

S Chatterjee, S Kundu, A Bhattacharyya - Toxicology letters, 2008 - Elsevier
Cadmium is the major component of polluted environment which can be fatal by
mechanisms that are not fully clear. Our study indicates immunosupression may be one of …

Cadmium-induced apoptosis in human normal liver L-02 cells by acting on mitochondria and regulating Ca2+ signals

JL Ye, WP Mao, AL Wu, NN Zhang, C Zhang… - Environmental …, 2007 - Elsevier
Cadmium is a well-known toxic compound for the liver. It has been demonstrated to induce
hepatotoxicity partly via apoptosis, but no uniform mechanism of apoptosis has so far been …