Peripheral inflammation and blood–brain barrier disruption: effects and mechanisms

X Huang, B Hussain, J Chang - CNS neuroscience & …, 2021 - Wiley Online Library
The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

[HTML][HTML] The blood-brain barrier in systemic inflammation

A Varatharaj, I Galea - Brain, behavior, and immunity, 2017 - Elsevier
The blood-brain barrier (BBB) plays a key role in maintaining the specialized
microenvironment of the central nervous system (CNS), and enabling communication with …

Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for …

F Takata, S Nakagawa, J Matsumoto… - Frontiers in cellular …, 2021 - frontiersin.org
Neuroinflammation is involved in the onset or progression of various neurodegenerative
diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage …

Blood–brain barrier and its function during inflammation and autoimmunity

SA Sonar, G Lal - Journal of Leukocyte Biology, 2018 - academic.oup.com
The blood–brain barrier (BBB) is an important physiologic barrier that separates CNS from
soluble inflammatory mediators and effector immune cells from peripheral circulation. The …

The blood–brain barrier in neurodegenerative disease: a rhetorical perspective

PM Carvey, B Hendey… - Journal of …, 2009 - Wiley Online Library
Recent studies suggest that the function of the blood–brain barrier (BBB) is not static under
normal physiologic conditions and is likely altered in neurodegenerative disease. Prevailing …

The blood-brain barrier and its role in immune privilege in the central nervous system

JS Pachter, HE de Vries, Z Fabry - Journal of Neuropathology & …, 2003 - academic.oup.com
The blood-brain barrier (BBB) provides both anatomical and physiological protection for the
central nervous system (CNS), strictly regulating the entry of many substances and blood …

The blood–brain barrier

B Obermeier, A Verma, RM Ransohoff - Handbook of clinical neurology, 2016 - Elsevier
In autoimmune neurologic disorders, the blood–brain barrier (BBB) plays a central role in
immunopathogenesis, since this vascular interface is an entry path for cells and effector …

The blood–brain barrier and immune function and dysfunction

WA Banks, MA Erickson - Neurobiology of disease, 2010 - Elsevier
The blood–brain barrier (BBB) is the monocellular interface that divides the peripheral
circulation from direct contact with the central nervous system (CNS). This interface consists …

Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier

MA Erickson, K Dohi, WA Banks - Neuroimmunomodulation, 2012 - karger.com
The blood-brain barrier (BBB) is not simply a physical barrier but a regulatory interface
between the central nervous system (CNS) and immune system. The BBB both affects and is …

The role of the blood–brain barrier during neurological disease and infection

A Patabendige, D Janigro - Biochemical Society Transactions, 2023 - portlandpress.com
A healthy brain is protected by the blood–brain barrier (BBB), which is formed by the
endothelial cells that line brain capillaries. The BBB plays an extremely important role in …