Despite numerous studies on the neurobiology of depression, the etiological and
pathophysiological mechanisms of this disorder remain poorly understood. A large number …

The 2-bottle choice procedure for assessing sucrose preference is a useful test to
investigate anhedonia (ie, inability to feel pleasure) in laboratory rodents, particularly in …

Depression is a highly prevalent and debilitating condition, only partially addressed by
current pharmacotherapies. The lack of response to treatment by many patients prompts the …

Anhedonia is the decreased ability to experience pleasure from rewarding or enjoyable
activities, a core symptom of depression. The sucrose preference test (SPT), based on a two …

The sucrose preference test (SPT) is a reward-based test, used as in indicator of anhedonia.
Anhedonia, or the decreased ability to experience pleasure, represents one of the core …

Anhedonia is the inability to experience pleasure from rewarding or enjoyable activities and
is a core symptom of depression in humans. Here, we describe a protocol for the …

Many studies with chronic stress, a common depression paradigm, lead to inconsistent
behavioral results. We are introducing a new model of stress-induced anhedonia, which …

Sucrose consumption and preference were examined in rats subjected to a 6-week regimen
of unpredictable mild stressors, after Willner et al.[11]. These subjects were compared with …

Replies to the 16 commentaries on the article by P. Willner (1997) concerning the validity
and reliability of the chronic mild stress (CMS) model of depression. The author corrects …

Stress, especially chronic stress, is one of the most important factors responsible for
precipitation of affective disorders in humans. The animal models commonly used in the …