Abstract Wilms' tumor (WT), the most common childhood kidney cancer, develops in
association with an underlying germline predisposition in up to 15% of cases. Germline …

Background Studies suggest that Wilms tumours (WT) are caused by underlying genetic (5%–
10%) and epigenetic (2%–29%) mechanisms, yet studies covering both aspects are sparse …

Purpose Constitutional WT1 mutations in patients with Wilms' tumor (WT) have specifically
been associated with genitourinary abnormalities, such as cryptorchidism and hypospadias …

Abstract Background Wilms Tumor (WT) can occur in association with tumor predisposition
syndromes and/or with clinical malformations. These associations have not been fully …

INTRODUCTION: In 9–17% of Wilms tumour patients a predisposing syndrome is present, in
particular WT1-associated syndromes and overgrowth syndromes. Constitutional WT1 …

Even before Knudson's two hit hypothesis was proven at a molecular level for
retinoblastoma, there was emerging evidence that the genetics of Wilms tumor involved …

Wilms tumour has been reported in association with over 50 different clinical conditions and
several abnormal constitutional karyotypes. Conclusive evidence of an increased risk of …

Approximately 5% of patients with Wilms tumor present with synchronous bilateral disease.
The development of synchronous bilateral Wilms tumor (BWT) is highly suggestive of a …

Clinicians have long recognized the syndromic association between Wilms tumor and a
variety of genetic disorders. The recent identification of molecular mechanisms associated …

PURPOSE Wilms tumor (WT) is associated with (epi) genetic predisposing factors affecting a
growing number of WT predisposing genes and loci, including those causing Beckwith …