Most aspects of the molecular biology of cells involve tightly coordinated intermolecular
interactions requiring specific recognition at the nucleotide and/or amino acid levels. This …

When an advantageous mutation is fixed in a population by selection, a closely linked
selectively neutral or mildly detrimental mutation may" hitchhike" to fixation along with it. It …

One of the great metaphors of evolutionary biology, introduced by Sewall Wright, is that
populations evolve toward adaptive peaks separated by adaptive valleys. The peaks are …

The phenotypic effects of random mutations depend on both the architecture of the genome
and the gene–trait relationships. Both levels thus play a key role in the mutational variability …

The production and maintenance of genetic and phenotypic diversity under temporally
fluctuating selection and the signatures of environmental changes in the patterns of this …

Intragenic recombination rapidly creates protein sequence diversity compared with random
mutation, but little is known about the relative effects of recombination and mutation on …

Random drift, while indifferent to the functionality of the molecular features on which it acts,
may nevertheless affect evolving molecular mechanisms. It can lead to functional novelty in …

Recent observations on rates of mutation, recombination, and random genetic drift highlight
the dramatic ways in which fundamental evolutionary processes vary across the divide …

Positive selection distorts the structure of genealogies and hence alters patterns of genetic
variation within a population. Most analyses of these distortions focus on the signatures of …

Many cellular functions depend on highly specific intermolecular interactions, for example
transcription factors and their DNA binding sites, microRNAs and their RNA binding sites …