Almost all currently available treatments for inflammatory bowel disease (IBD) act by
inhibiting inflammation, often blocking specific inflammatory molecules. However, given the …

Mucosal healing (MH) is vital in maintaining homeostasis within the gut and protecting
against injury and infections. Multiple factors and signaling pathways contribute in a …

Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …

Healing of the inflamed mucosa (mucosal healing) is an emerging new goal for therapy and
predicts clinical remission and resection-free survival in inflammatory bowel diseases …

The human gut relies on several cellular and molecular mechanisms to allow for an intact
and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the …

Despite significant recent therapeutic advances, complete mucosal healing remains a
difficult treatment target for many patients with inflammatory bowel diseases (IBD) to …

In the past decades, continuous effort has been paid to deeply understanding the
pathophysiology of inflammatory bowel diseases (IBD), such as ulcerative colitis or Crohn's …

The mammalian intestine is the largest immune organ that contains the intestinal stem cells
(ISC), differentiated epithelial cells (enterocytes, Paneth cells, goblet cells, tuft cells, etc.) …

Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …

The intestinal epithelial barrier is carrying out two major functions: restricting the entry of
potentially harmful substances while on the other hand allowing the selective passage of …