Cytochrome p450 and vascular homeostasis
I Fleming - Circulation research, 2001 - Am Heart Assoc
Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …
Epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid on endothelial and vascular function
JD Imig - Advances in pharmacology, 2016 - Elsevier
Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid
metabolites that can impact endothelial cell function and vascular homeostasis. The …
metabolites that can impact endothelial cell function and vascular homeostasis. The …
Vascular cytochrome p450 enzymes: physiology and pathophysiology
I Fleming - Trends in cardiovascular medicine, 2008 - Elsevier
Cytochrome P450 epoxygenases and the soluble epoxide hydrolase are enzymes that
regulate the cellular content of bioactive epoxides such as the epoxyeicosatrienoic acids …
regulate the cellular content of bioactive epoxides such as the epoxyeicosatrienoic acids …
Cytochrome P450 pathways of arachidonic acid metabolism
Cytochrome P450s metabolize arachidonic acid to hydroxyeicosatetraenoic acids and
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …
epoxyeicosatrienoic acids. These eicosanoids are formed in a tissue and cell-specific …
Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease
OBJECTIVE: Preclinical and genetic epidemiologic studies suggest that modulating
cytochrome P450 (CYP)-mediated arachidonic acid metabolism may have therapeutic utility …
cytochrome P450 (CYP)-mediated arachidonic acid metabolism may have therapeutic utility …
The CYP4A isoforms hydroxylate epoxyeicosatrienoic acids to form high affinity peroxisome proliferator-activated receptor ligands
LA Cowart, S Wei, MH Hsu, EF Johnson… - Journal of Biological …, 2002 - ASBMB
Cytochromes P450 of the CYP2Cand CYP4A gene subfamilies metabolize arachidonic acid
to 5, 6-, 8, 9-, 11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs) and to 19-and 20 …
to 5, 6-, 8, 9-, 11, 12-, and 14, 15-epoxyeicosatrienoic acids (EETs) and to 19-and 20 …
Vascular protective effects of cytochrome p450 epoxygenase-derived eicosanoids
M Spiecker, JK Liao - Archives of biochemistry and biophysics, 2005 - Elsevier
Cytochrome P450 epoxygenases metabolize arachidonic acid to biologically active
eicosanoids. Primary epoxidation products are four regioisomers of cis-epoxyeicosatrienoic …
eicosanoids. Primary epoxidation products are four regioisomers of cis-epoxyeicosatrienoic …
The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases
X Xu, XA Zhang, DW Wang - Advanced drug delivery reviews, 2011 - Elsevier
Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active
eicosanoids. The primary epoxidation products are four regioisomers of cis …
eicosanoids. The primary epoxidation products are four regioisomers of cis …
Cytochrome P450-derived eicosanoids and heart function
KL Jamieson, T Endo, AM Darwesh… - Pharmacology & …, 2017 - Elsevier
The cytochrome P450 monooxygenase system (CYP) is a multigene superfamily of
enzymes, which are important in the metabolism of foreign and endogenous compounds …
enzymes, which are important in the metabolism of foreign and endogenous compounds …
Cytochrome P450, the arachidonic acid cascade, and hypertension: new vistas for an old enzyme system
K Makita, JR Falck, JH Capdevila - The FASEB journal, 1996 - Wiley Online Library
As a participant of the endogenous arachidonic acid metabolic cascade, microsomal cy‐
tochrome P450 metabolizes the fatty acid to biologi‐cally active hydroxyeicoeatetraenoic …
tochrome P450 metabolizes the fatty acid to biologi‐cally active hydroxyeicoeatetraenoic …