Role of splanchnic circulation in the pathogenesis of heart failure: State-of-the-art review

H Yaku, M Fudim, SJ Shah - Journal of Cardiology, 2024 - Elsevier
A hallmark of heart failure (HF), whether it presents itself during rest or periods of physical
exertion, is the excessive elevation of intracardiac filling pressures at rest or with exercise …

[HTML][HTML] Splanchnic nerve ablation for volume management in heart failure

M Fudim, ZJ Engelman, VY Reddy, SJ Shah - Basic to Translational …, 2022 - jacc.org
Elevated left-side filling pressures at rest and particularly during exertion are well described
prognostic indicators and targets for cardiovascular therapies with the intention to improve …

TCT-432 greater splanchnic nerve ablation in chronic heart failure: preserved versus reduced left ventricular ejection fraction

V Reddy, H Sievert, T Zirakashvili, F Málek… - Journal of the American …, 2021 - jacc.org
Background In chronic heart failure (HF), increased sympathetic-mediated splanchnic
vasoconstriction causes inappropriate redistribution of blood into the central circulation …

Targeting preload in heart failure: splanchnic nerve blockade and beyond

M Fudim, MS Khan, AA Paracha… - Circulation: Heart …, 2022 - Am Heart Assoc
Preload augmentation represents a critical mechanism for the cardiovascular system to
increase effective circulating blood volume to increase cardiac filling pressures and …

Endovascular ablation of the right greater splanchnic nerve in heart failure with preserved ejection fraction: early results of the REBALANCE‐HF trial roll‐in cohort

M Fudim, PS Fail, SE Litwin… - European journal of …, 2022 - Wiley Online Library
Aims In heart failure (HF) with preserved ejection fraction (HFpEF), excessive redistribution
of blood volume into the central circulation leads to elevations of intracardiac pressures with …

[HTML][HTML] Endovascular Ablation of the Right Greater Splanchnic Nerve in Heart Failure With Preserved Ejection Fraction: Rationale, Design and Lead-in Phase Results …

M Fudim, SE Litwin, BA Borlaug, RC Mohan… - Journal of Cardiac …, 2024 - Elsevier
Objective Splanchnic vasoconstriction augments transfer of blood volume from the abdomen
into the thorax, which may increase filling pressures and hemodynamic congestion in …

The role of splanchnic congestion and the intestinal microenvironment in the pathogenesis of advanced heart failure

VB Polsinelli, L Marteau, SJ Shah - Current opinion in supportive …, 2019 - journals.lww.com
The role of splanchnic congestion and the intestinal microen... : Current Opinion in
Supportive and Palliative Care The role of splanchnic congestion and the intestinal …

[HTML][HTML] The splanchnic reservoir: an oasis for blood volume in heart failure with preserved ejection fraction?

RB Patel, SJ Shah - European journal of heart failure, 2021 - ncbi.nlm.nih.gov
Although its pathogenesis is multifaceted, heart failure (HF) with preserved ejection fraction
(HFpEF) is defined as a syndrome of elevated left ventricular (LV) filling pressures at rest or …

Surgical ablation of the right greater splanchnic nerve for the treatment of heart failure with preserved ejection fraction: first‐in‐human clinical trial

F Málek, P Gajewski, R Zymliński… - European journal of …, 2021 - Wiley Online Library
Aims Inappropriate control of blood volume redistribution may be a mechanism responsible
for exercise intolerance in heart failure with preserved ejection fraction (HFpEF). We …

Splanchnic nerve block mediated changes in stressed blood volume in heart failure

M Fudim, MR Patel, R Boortz-Marx, BA Borlaug… - Heart Failure, 2021 - jacc.org
Objectives The authors estimated changes of stressed blood volume (SBV) induced by
splanchnic nerve block (SNB) in patients with either decompensated or ambulatory heart …