Payload diversification: a key step in the development of antibody–drug conjugates

L Conilh, L Sadilkova, W Viricel, C Dumontet - Journal of Hematology & …, 2023 - Springer
Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that
currently combines the selectivity of monoclonal antibodies with the potency of a payload …

Antibody–drug conjugates (ADCs) for personalized treatment of solid tumors: a review

JM Lambert, CQ Morris - Advances in therapy, 2017 - Springer
Attaching a cytotoxic “payload” to an antibody to form an antibody–drug conjugate (ADC)
provides a mechanism for selective delivery of the cytotoxic agent to cancer cells via the …

The next generation of antibody drug conjugates

F Mack, M Ritchie, P Sapra - Seminars in oncology, 2014 - Elsevier
Antibody-drug conjugates (ADCs) represent a promising therapeutic modality for the clinical
management of cancer. The recent approvals of brentuximab vedotin and ado-trastuzumab …

Antibody–drug conjugates in solid tumors: a look into novel targets

C Criscitiello, S Morganti, G Curigliano - Journal of hematology & oncology, 2021 - Springer
Antibody–drug conjugates (ADCs) are a relatively new class of anticancer agents designed
to merge the selectivity of monoclonal antibodies with cell killing properties of …

Targeting cancer with antibody-drug conjugates: Promises and challenges

AQ Dean, S Luo, JD Twomey, B Zhang - MAbs, 2021 - Taylor & Francis
Antibody-drug conjugates (ADCs) are a rapidly expanding class of biotherapeutics that
utilize antibodies to selectively deliver cytotoxic drugs to the tumor site. As of May 2021, the …

Antibody–drug conjugates: The last decade

N Joubert, A Beck, C Dumontet, C Denevault-Sabourin - Pharmaceuticals, 2020 - mdpi.com
An armed antibody (antibody–drug conjugate or ADC) is a vectorized chemotherapy, which
results from the grafting of a cytotoxic agent onto a monoclonal antibody via a judiciously …

Antibody–drug conjugates as novel anti-cancer chemotherapeutics

C Peters, S Brown - Bioscience reports, 2015 - portlandpress.com
Over the past couple of decades, antibody–drug conjugates (ADCs) have revolutionized the
field of cancer chemotherapy. Unlike conventional treatments that damage healthy tissues …

Effects of drug–antibody ratio on pharmacokinetics, biodistribution, efficacy, and tolerability of antibody–maytansinoid conjugates

X Sun, JF Ponte, NC Yoder, R Laleau… - Bioconjugate …, 2017 - ACS Publications
Antibody–drug conjugates (ADCs) are being actively pursued as a treatment option for
cancer following the regulatory approval of brentuximab vedotin (Adcetris) and ado …

Site-specific trastuzumab maytansinoid antibody–drug conjugates with improved therapeutic activity through linker and antibody engineering

TH Pillow, J Tien, KL Parsons-Reponte… - Journal of medicinal …, 2014 - ACS Publications
Antibody–drug conjugates (ADCs) have a significant impact toward the treatment of cancer,
as evidenced by the clinical activity of the recently approved ADCs, brentuximab vedotin for …

Strategies and challenges for the next generation of antibody–drug conjugates

A Beck, L Goetsch, C Dumontet… - Nature reviews Drug …, 2017 - nature.com
Antibody–drug conjugates (ADCs) are one of the fastest growing classes of oncology
therapeutics. After half a century of research, the approvals of brentuximab vedotin (in 2011) …