An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

The kidney is among the most complex organs in terms of the variety of cell types. The
cellular complexity of human kidneys is not fully unraveled and this challenge is further …

Breakthroughs in the development of high-throughput technologies for profiling
transcriptomes at the single-cell level have helped biologists to understand the …

The assignment of cell type names to individual cell clusters in single-cell RNA-sequencing
(RNA-seq; including single-nucleus RNA-seq) studies is a critical bioinformatic step …

The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …

Recent techniques for single-cell RNA sequencing (scRNA-seq) at high throughput are
leading to profound new discoveries in biology. The ability to generate vast amounts of …

Bulk-tissue RNA-Seq is increasingly being used in the study of physiological and
pathophysiological processes in the kidney; however, the presence of multiple cell types in …

A revolution in cellular measurement technology is underway. Whereas prior studies have
been able to analyze only the averaged outputs from renal tissue, we now can accurately …

Molecular characterization of the individual cell types in human kidney as well as model
organisms are critical in defining organ function and understanding translational aspects of …

Background Three different cell types constitute the glomerular filter: mesangial cells,
endothelial cells, and podocytes. However, to what extent cellular heterogeneity exists …