[HTML][HTML] Synaptic reshaping and neuronal outcomes in the temporal lobe epilepsy

E Ren, G Curia - International Journal of Molecular Sciences, 2021 - mdpi.com
Temporal lobe epilepsy (TLE) is one of the most common types of focal epilepsy,
characterized by recurrent spontaneous seizures originating in the temporal lobe (s), with …

Epilepsy: disease and model to study human brain function

CE Elger - Brain pathology, 2002 - ncbi.nlm.nih.gov
Epilepsy is one of the most common neurological disorders, affecting almost 1% of the
population. In many patients, a focal onset of seizure activity within the temporal lobe can be …

[HTML][HTML] Pathological targets for treating temporal lobe epilepsy: discoveries from microscale to macroscale

J You, H Huang, CTY Chan, L Li - Frontiers in Neurology, 2022 - frontiersin.org
Temporal lobe epilepsy (TLE) is one of the most common and severe types of epilepsy,
characterized by intractable, recurrent, and pharmacoresistant seizures. Histopathology of …

Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue

M Majores, S Schoch, A Lie, AJ Becker - Epilepsia, 2007 - Wiley Online Library
Patients with temporal lobe epilepsies (TLE) frequently develop pharmacoresistance to
antiepileptic treatment. In individuals with drug‐refractory TLE, neurosurgical removal of the …

Gene expression profile in temporal lobe epilepsy

E Aronica, JA Gorter - The Neuroscientist, 2007 - journals.sagepub.com
Epilepsy is one of the most common neurological disorders. Temporal lobe epilepsy (TLE)
represents the most frequent epilepsy syndrome in adult patients with resistance to …

The role of synaptic reorganization in mesial temporal lobe epilepsy

JE Cavazos, DJ Cross - Epilepsy & Behavior, 2006 - Elsevier
The mechanisms underlying mesial temporal lobe epilepsy (MTLE) remain uncertain.
Putative mechanisms should account for several features characteristic of the clinical …

Mapping seizure pathways in the temporal lobe

DC McIntyre, KL Gilby - Epilepsia, 2008 - Wiley Online Library
Interest in temporal lobe seizure pathways has a long history based initially on the human
condition of temporal lobe epilepsy (TLE). This interest in TLE has extended more recently …

“Epileptic neurons” in temporal lobe epilepsy

Y Yaari, H Beck - Brain pathology, 2002 - ncbi.nlm.nih.gov
Epilepsy is a devastating chronic neurological disorder that affects about 0.8% of the
population worldwide. The clinical hallmark of epilepsy is recurrent seizures, which consist …

Neurogenesis in the hippocampus of patients with temporal lobe epilepsy

Q Zhong, BX Ren, FR Tang - Current neurology and neuroscience reports, 2016 - Springer
The mobilization of endogenous neural stem cells in order to substitute lost neurons in the
adult brain may reduce the negative effects of patients with chronic neurodegenerative …

Molecular neuropathology of human mesial temporal lobe epilepsy

I Blümcke, H Beck, AA Lie, OD Wiestler - Epilepsy research, 1999 - Elsevier
With the recent progress in surgical treatment modalities, human brain tissue from patients
with intractable focal epilepsies will increasingly become available for studies on the …