Role of oxidative stress in sclerotial differentiation and aflatoxin B1 biosynthesis in Aspergillus flavus

K Grintzalis, SI Vernardis, MI Klapa… - Applied and …, 2014 - Am Soc Microbiol
We show here that oxidative stress is involved in both sclerotial differentiation (SD) and
aflatoxin B1 biosynthesis in Aspergillus flavus. Specifically, we observed that (i) oxidative …

Aflatoxins are natural scavengers of reactive oxygen species

E Finotti, A Parroni, M Zaccaria, M Domin, B Momeni… - Scientific Reports, 2021 - nature.com
The role of aflatoxins (AFs) in the biology of producing strains, Aspergillus sect. Flavi, is still
a matter of debate. Over recent years, research has pointed to how environmental factors …

Elucidation of veA-dependent genes associated with aflatoxin and sclerotial production in Aspergillus flavus by functional genomics

JW Cary, GR OBrian, DM Nielsen, W Nierman… - Applied microbiology …, 2007 - Springer
The aflatoxin-producing fungi, Aspergillus flavus and A. parasiticus, form structures called
sclerotia that allow for survival under adverse conditions. Deletion of the veA gene in A …

Responses of Aspergillus flavus to Oxidative Stress Are Related to Fungal Development Regulator, Antioxidant Enzyme, and Secondary Metabolite Biosynthetic …

JC Fountain, P Bajaj, SN Nayak, L Yang… - Frontiers in …, 2016 - frontiersin.org
The infection of maize and peanut with Aspergillus flavus and subsequent contamination
with aflatoxin pose a threat to global food safety and human health, and is exacerbated by …

Oxidant/antioxidant balance inAspergillus parasiticus affects aflatoxin biosynthesis

M Reverberi, S Zjalic, A Ricelli, AA Fabbri, C Fanelli - Mycotoxin Research, 2006 - Springer
A close correlation between lipoperoxide formation in cells of Aspergillus parasiticus and
aflatoxin biosynthesis has been established in rich and poor media in which oxidative stress …

Association of aflatoxin biosynthesis and sclerotialdevelopment in Aspergillus parasiticus

PK Chang, JW Bennett, PJ Cotty - Mycopathologia, 2002 - Springer
Secondary metabolism in fungi is frequently associated with asexual and sexual
development. Aspergillus parasiticus produces aflatoxins known to contaminate a variety of …

Molecular mechanisms of Aspergillus flavus secondary metabolism and development

MG Amare, NP Keller - Fungal Genetics and Biology, 2014 - Elsevier
The plant and human opportunistic fungus Aspergillus flavus is recognized for the
production of the carcinogen aflatoxin. Although many reviews focus on the wealth of …

Effect of climate change on Aspergillus flavus and aflatoxin B1 production

A Medina, A Rodriguez, N Magan - Frontiers in microbiology, 2014 - frontiersin.org
This review considers the available information on the potential impact of key environmental
factors and their interactions on the molecular ecology, growth and aflatoxin production by …

Oxidative stress as a prerequisite for aflatoxin production by Aspergillus parasiticus

T Jayashree, C Subramanyam - Free Radical Biology and Medicine, 2000 - Elsevier
The relevance of free radical generation and oxidative stress with regard to aflatoxin
production was examined by comparing the oxygen requirement and antioxidant status of a …

Oxidative stress-related transcription factors in the regulation of secondary metabolism

SY Hong, LV Roze, JE Linz - Toxins, 2013 - mdpi.com
There is extensive and unequivocal evidence that secondary metabolism in filamentous
fungi and plants is associated with oxidative stress. In support of this idea, transcription …