Location, location, location: Tissue resident memory T cells in mice and humans

PA Szabo, M Miron, DL Farber - Science immunology, 2019 - science.org
The discovery of T cells resident in diverse tissues has altered our understanding of
adaptive immunity to encompass site-specific responses mediated by tissue-adapted …

Emerging concepts in tissue-resident T cells: lessons from humans

JJC Thome, DL Farber - Trends in immunology, 2015 - cell.com
Intensified efforts to promote protective T cell-based immunity in vaccines and
immunotherapies have created a compelling need to expand our understanding of human T …

Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites

BV Kumar, W Ma, M Miron, T Granot, RS Guyer… - Cell reports, 2017 - cell.com
Tissue-resident memory T cells (TRMs) in mice mediate optimal protective immunity to
infection and vaccination, while in humans, the existence and properties of TRMs remain …

Tissue-resident memory CD8+ T cells possess unique transcriptional, epigenetic and functional adaptations to different tissue environments

JT Crowl, M Heeg, A Ferry, JJ Milner, KD Omilusik… - Nature …, 2022 - nature.com
Tissue-resident memory T cells (TRM cells) provide protective immunity, but the
contributions of specific tissue environments to TRM cell differentiation and homeostasis are …

Tissue adaptation and clonal segregation of human memory T cells in barrier sites

MML Poon, DP Caron, Z Wang, SB Wells, D Chen… - Nature …, 2023 - nature.com
T lymphocytes migrate to barrier sites after exposure to pathogens, providing localized
immunity and long-term protection. Here, we obtained blood and tissues from human organ …

Tissue-resident memory T cells

JM Schenkel, D Masopust - Immunity, 2014 - cell.com
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that
occupies tissues without recirculating. They provide a first response against infections …

Migration, maintenance and recall of memory T cells in peripheral tissues

DL Woodland, JE Kohlmeier - Nature Reviews Immunology, 2009 - nature.com
After the resolution of an immune response, antigen-specific memory T cells persist at many
sites in the body. The antigen-specific memory T-cell pool includes memory T cells that …

Tissue-resident memory T cells: local specialists in immune defence

SN Mueller, LK Mackay - Nature Reviews Immunology, 2016 - nature.com
T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Cutting edge: tissue-resident memory T cells generated by multiple immunizations or localized deposition provide enhanced immunity

B Davies, JE Prier, CM Jones, T Gebhardt… - The Journal of …, 2017 - journals.aai.org
Tissue-resident memory T cells (T RM) have been shown to afford superior protection
against infection, particularly against pathogens that enter via the epithelial surfaces of the …

Tissue‐resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

T Gebhardt, U Palendira, DC Tscharke… - Immunological …, 2018 - Wiley Online Library
A large proportion of memory T cells disseminated throughout the body are non‐
recirculating cells whose maintenance and function is regulated by tissue‐specific …