The sequence of chromosome 21 was a turning point for the understanding of Down
syndrome. Comparative genomics is beginning to identify the functional components of the …

Down syndrome (also known as trisomy 21) is the model human phenotype for all genomic
gain dosage imbalances, including microduplications. The functional genomic exploration of …

Down syndrome is a common disorder affecting many tissues both during development and
later on in adult life; the principle feature of all cases is a specific form of mental retardation …

The recent completion of the DNA sequence of human chromosome 21 has provided the
first look at the 225 genes that are candidates for involvement in Down syndrome (trisomy …

Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …

Down syndrome caused by chromosome 21 trisomy is the most common genetic cause of
mental retardation in humans. Disruption of the phenotype is thought to be the result of gene …

The entire DNA sequence for human chromosome 21 is now complete, and it is predicted to
contain only about 225 genes, which is approximately three-fold fewer than the number …

The molecular mechanisms underlying the specific traits in individuals with Down syndrome
(DS) have been postulated to derive either from nonspecific perturbation of balanced …

Down syndrome is a collection of features that are caused by trisomy for human
Chromosome 21. While elevated transcript levels of the more than 350 genes on the …

Down syndrome (DS) results from complete or partial triplication of human chromosome 21.
It is assumed that the neurological and other symptoms are caused by the overexpression of …