This protocol presents the use of SARS-CoV-2 isolates to infect human kidney organoids,
enabling exploration of the impact of SARS-CoV-2 infection in a human multicellular in vitro …

Induced pluripotent stem cell (iPSC)-derived kidney organoids can be used for disease
modeling and drug testing. Here, we describe a protocol to prepare stocks of an infectious …

We describe a protocol for single-cell RNA sequencing of SARS-CoV-2-infected human
induced pluripotent stem cell (iPSC)-derived kidney organoids. After inoculation of kidney …

Early in the pandemic, diabetes was recognized as a risk factor for poor prognosis in
patients with coronavirus disease 2019 (COVID-19). Although diabetes does not appear to …

Abstract The coronavirus disease 2019 (COVID-19) global pandemic caused by the novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected over 200 …

SARS-CoV-2 can cause diverse severe and lasting damage to the kidneys. In the latest
issue of Cell Stem Cell, Jansen et al. utilized data gleaned from human kidney autopsies …

SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for
physiological models to study SARS-CoV-2 infection using human disease-relevant cells …

Kidney failure is frequently observed during and after COVID-19, but it remains elusive
whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects …

Context: The clinical course of coronavirus disease-19 (COVID-19) can be complicated by
acute kidney injury and proteinuria. Kidney cells express receptors for SARS-CoV-2, the …

COVID-19-associated acute kidney injury (COVID-AKI) is a common complication of SARS-
CoV-2 infection in hospitalized patients. The susceptibility of human kidneys to direct SARS …