The question of whether multiple mutations within a protein sum additively or nonadditively has fascinated investigators for more than a decade, both because of the potential …
AS Mildvan, DJ Weber, A Kuliopulos - Archives of biochemistry and …, 1992 - Elsevier
The quantitative effect of a second mutation on a mutant enzyme may be antagonistic, absent, partially additive, additive, or synergistic with respect to the first mutation. Depending …
T Alber - Annual review of biochemistry, 1989 - annualreviews.org
The study of protein stability is changing dramatically. In the last decade, improvements in genetic and biophysical methods have facilitated measure ments of the stabilizing …
LM Gregoret, RT Sauer - Proceedings of the National …, 1993 - National Acad Sciences
Eleven amino acid positions in the helix-turn-helix of lambda repressor have been mutagenized by using a combinatorial method in which alanine is substituted at each …
Department of Chemistry, Imperial College of Science and Technology, London SW7 2AY, UK Received June 15, 1987; Revised Manuscript Received October 1, 1987 abstract: The …
AE Mark, WF Van Gunsteren - Journal of molecular biology, 1994 - Elsevier
Recently, a number of methods have been proposed that are designed to extract contributions to the change in free energy associated with a given perturbation or mutation …
WE Stites - Chemical reviews, 1997 - ACS Publications
It is difficult to overstate the importance of proteinprotein interactions in biological processes. Some of these interactions and their roles are well known, for instance, the formation of …
D Shortle - Quarterly reviews of biophysics, 1992 - cambridge.org
The fundamental relationship between structure and function has served to guide investigations into the workings of living systems at all levels-from the whole organism to …
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