A variety of substituted isocoumarins and α-pyrones are readily prepared in excellent yields
under very mild reaction conditions by the reaction of o-(1-alkynyl) benzoates and (Z)-2 …

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A general route to α-pyrones and 3-substituted isocoumarins from (Z)-iodovinylic acids 1a− f
or 2-iodobenzoic acids 4a− c is described, including compounds bearing a substituent on …

The solution-phase synthesis of a 167-member library of isocoumarins is described. The key
intermediates for library generation, 4-iodoisocoumarins, are easily prepared by …

Being an important constituent of naturally occurring lactones with diverse biological
activities and as a pivotal intermediate in heterocycle synthesis, the isocoumarin motif has …

This article reviews the most recent developments in the synthesis of isocoumarins and 3, 4-
dihydroisocoumarins (isochroman-1-ones), that is, compounds incorporating the …

A simple and efficient metal-free sulfenylation/cyclization of aryl alkynoates has been
developed, obtaining various 3-sulfenylated coumarins in moderate to excellent yields. In …

A variety of 2-hydroxy aldehydes on reaction with 3-butenoic acid afford in a one-pot
reaction the corresponding 3-vinylcoumarins. As expected, extension of the delocalized π …

A novel synthesis of coumarins based on the ortho-directed metalation of methoxymethyl
phenolic ethers with alkyllithium reagents is described. The method entails reaction of the …

An improved one-pot synthesis of 4-hydroxycoumarin, 4-hydroxythiocoumarin, and 4-
hydroxyquinolin-2 (1 H)-one from 2-hydroxyacetophenone, 2-mercaptoacetophenone, and 2 …