Early prediction of clearance mechanisms allows for the rapid progression of drug discovery
and development programs, and facilitates risk assessment of the pharmacokinetic …

The Biopharmaceutics Classification System (BCS) is a scientific framework that provides a
basis for predicting the oral absorption of drugs. These concepts have been extended in the …

Due to its implications for both dose level and frequency, clearance rate is one of the most
important pharmacokinetic parameters to consider in the design of drug candidates …

Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans
is important to reduce the risk of failure during drug development. In addition, when …

The biopharmaceutics classification system (BCS) and biopharmaceutics drug distribution
classification system (BDDCS) are complementary classification systems that can improve …

The in vitro–in vivo extrapolation (IVIVE) approach for predicting total plasma clearance
(CLtot) has been widely used to rank order compounds early in discovery. More recently, a …

No Heading The Biopharmaceutics Classification System (BCS) was developed to allow
prediction of in vivo pharmacokinetic performance of drug products from measurements of …

Importance of the field: Kidney plays a key role in the elimination of xenobiotics and
metabolic products from the body, where renal clearance is determined by glomerular …

Introduction: Drug transporters play an important role in the absorption, distribution, and
excretion (ADE) of many drugs. In the last several years it has become increasingly clear …

A Biopharmaceutics Drug Disposition Classification System (BDDCS) was proposed to
serve as a basis for predicting the importance of transporters in determining drug …