Stimulator of interferons genes (STING), which is crucial for the secretion of type I interferons
and proinflammatory cytokines in response to cytosolic nucleic acids, plays a key role in the …

Background Traumatic brain injury (TBI) represents a major cause of disability and death
worldwide with sustained neuroinflammation and autophagy dysfunction contributing to the …

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate
the progression of many CNS pathologies both acute and chronic. The role of adaptor …

STING is a newly identified intracellular sensor of foreign and endogenous DNA. STING has
been recognized as an activator of immune responses by TBK1/IRF3 and NF‐κB pathways …

Long‐term neurological deficits after severe traumatic brain injury (TBI), including cognitive
dysfunction and emotional impairments, can significantly impair rehabilitation. Glial …

Background Neuroinflammation-induced injury is intimately associated with poor prognosis
in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase …

Abstract The Stimulator of Interferon Genes (STING) is predominantly expressed in immune
cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a …

Stimulator of interferon genes (STING) is activated after detection of cytoplasmic dsDNA by
cGAS (cyclic GMP-AMP synthase) as part of the innate immunity defence against viral …

Background Stimulation of IFN genes (STING) is central to the production of interferon and
proinflammatory cytokines in response to microbial DNA or self-DNA in the cytosol. The …

Innate immunity is regulated by a broad set of evolutionary conserved receptors to finely
probe the local environment and maintain host integrity. Besides pathogen recognition …