The inflammatory response is one of the host's mechanisms to combat pathogens. Normal
and controlled inflammation can accelerate the clearance of pathogens. However, in sepsis …

Abstract Purpose Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the
gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Pyroptosis was long regarded as caspase-1-mediated monocyte death in response to
certain bacterial insults. Caspase-1 is activated upon various infectious and immunological …

Pyroptosis is an inflammatory form of cell death that not only protects multicellular organisms
from invading pathogenic bacteria and microbial infections, but can also lead to sepsis and …

Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming
effector proteins that facilitate inflammatory cell death, also known as pyroptosis. This type of …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Sepsis is recognized as a life‐threatening organ dysfunctional disease that is caused by
dysregulated host responses to infection. Up to now, sepsis still remains a dominant cause …

As an uncontrolled inflammatory response to infection, sepsis and sepsis induced organ
dysfunction are great threats to the lives of septic patients. Unfortunately, the pathogenesis …

Gasdermin D (GSDMD)-mediated pyroptosis and downstream inflammation are important
self-protection mechanisms against stimuli and infections. Hosts can defend against …