Mutations on RBD of SARS-CoV-2 Omicron variant result in stronger binding to human ACE2 receptor

CS Lupala, Y Ye, H Chen, XD Su, H Liu - Biochemical and biophysical …, 2022 - Elsevier
The COVID-19 pandemic caused by the SARS-CoV-2 virus has led to more than 270 million
infections and 5.3 million of deaths worldwide. Several major variants of SARS-CoV-2 have …

Scanning the RBD-ACE2 molecular interactions in Omicron variant

SL Rath, AK Padhi, N Mandal - Biochemical and biophysical research …, 2022 - Elsevier
The emergence of new SARS-CoV-2 variants poses a threat to the human population where
it is difficult to assess the severity of a particular variant of the virus. Spike protein and …

Binding interactions between receptor-binding domain of spike protein and human angiotensin converting enzyme-2 in omicron variant

B Jawad, P Adhikari, R Podgornik… - The journal of physical …, 2022 - ACS Publications
The emergence of new SARS-CoV-2 Omicron variant of concern (OV) has exacerbated the
COVID-19 pandemic because of a large number of mutations in the spike protein …

Comparing the binding interactions in the receptor binding domains of SARS-CoV-2 and SARS-CoV

M Amin, MK Sorour, A Kasry - The journal of physical chemistry …, 2020 - ACS Publications
SARS-CoV-2, since emerging in Wuhan, China, has been a major concern because of its
high infection rate and has left more than six million infected people around the world. Many …

Omicron BA. 1 and BA. 2 variants increase the interactions of SARS-CoV-2 spike glycoprotein with ACE2

M Golcuk, A Yildiz, M Gur - Journal of Molecular Graphics and Modelling, 2022 - Elsevier
SARS-CoV-2 infection is initiated by binding of the receptor-binding domain (RBD) of its
spike glycoprotein to the peptidase domain (PD) of angiotensin-converting enzyme 2 …

[HTML][HTML] Molecular dynamics simulations of the delta and omicron SARS-CoV-2 spike–ACE2 complexes reveal distinct changes between both variants

E Socher, L Heger, F Paulsen, F Zunke… - Computational and …, 2022 - Elsevier
Abstract SARS-CoV-2, the virus causing the COVID-19 pandemic, changes frequently
through the appearance of mutations constantly leading to new variants. However, only few …

Binding of human ACE2 and RBD of omicron enhanced by unique interaction patterns among SARS‐CoV‐2 variants of concern

S Kim, Y Liu, M Ziarnik, S Seo, Y Cao… - Journal of …, 2023 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus causing COVID‐
19, has continued to mutate and spread worldwide despite global vaccination efforts. In …

Omicron SARS-CoV-2 variant spike protein shows an increased affinity to the human ACE2 receptor: an in silico analysis

JT Ortega, B Jastrzebska, HR Rangel - Pathogens, 2021 - mdpi.com
The rise of SARS-CoV-2 variants, with changes that could be related to an increased virus
pathogenicity, have received the interest of the scientific and medical community. In this …

Assessment of mutations on RBD in the Spike protein of SARS-CoV-2 Alpha, Delta and Omicron variants

CHS da Costa, CAB de Freitas, CN Alves… - Scientific Reports, 2022 - nature.com
The severe acute respiratory syndrome (SARS) coronavirus 2 (CoV-2) variant Omicron
spread more rapid than the other variants of SARS-CoV-2 virus. Mutations on the Spike (S) …

The SARS-CoV-2 B. 1.618 variant slightly alters the spike RBD–ACE2 binding affinity and is an antibody escaping variant: a computational structural perspective

A Khan, J Gui, W Ahmad, I Haq, M Shahid, AA Khan… - RSC …, 2021 - pubs.rsc.org
Continuing reports of new SARS-CoV-2 variants have caused worldwide concern and
created a challenging situation for clinicians. The recently reported variant B. 1.618, which …