The protein Numb does not live up to its name. This passive-sounding protein is anything
but spent. Originally identified as a cell-fate determinant in Drosophila development, Numb …

Numb is an evolutionary conserved protein that plays critical roles in cell fate determination.
Mammalian Numb displays a higher degree of structural complexity compared to the …

NUMB, a plasma membrane-associated protein originally described in Drosophila, is
involved in determining cell function and fate during early stages of development. It is …

The biological antagonism between Notch and Numb controls the proliferative/differentiative
balance in development and homeostasis. Although altered Notch signaling has been …

NUMB is a cell fate determinant, which, by asymmetrically partitioning at mitosis, controls
cell fate choices by antagonising the activity of the plasma membrane receptor of the …

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and
differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect …

Inhibition of Notch signaling by Numb is critical for many cell fate decisions. In this study, we
demonstrate a more complex relationship between Notch and the two vertebrate Numb …

The cell fate determinant Numb influences developmental decisions by antagonizing the
Notch signaling pathway. However, the underlying molecular mechanism of this inhibition is …

NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary
conserved protein family implicated in some important cellular processes. Numb is a protein …

Glioblastoma contains a hierarchy of stem-like cancer cells, but how this hierarchy is
established is unclear. Here, we show that asymmetric Numb localization specifies …