Antipsychotic polypharmacy in schizophrenia is much debated, since it is common and
costly with unclear evidence for its efficacy and safety. We conducted a systematic literature …

Applying various psychopharmacological combination and augmentation strategies in
schizophrenia is common clinical practice. This meta-analysis evaluated the efficacy of …

Objective To evaluate the efficacy and safety of antidepressant augmentation of
antipsychotics in schizophrenia. Methods Systematic literature search (PubMed/MEDLINE …

Context: Despite lacking evidence for its safety and efficacy, antipsychotic cotreatment is
common in schizophrenia. Objective: To evaluate therapeutic and adverse effects of …

Background: Although clozapine is the most effective medication for treatment refractory
schizophrenia, only 40% of people will meet response criteria. We therefore undertook a …

Background Leading guidelines recommend antipsychotic (AP) monotherapy for
schizophrenia, nonetheless the combination of antipsychotics (polypharmacy) is common …

Limited options are available for clozapine-resistant schizophrenia and intolerable side
effects of clozapine. We conducted a systematic review of randomized-controlled trials …

Importance Limited treatment responses in schizophrenia prompted the testing of combining
an antipsychotic drug treatment with a second psychotropic medication. A comprehensive …

This systematic review and meta-analysis examined predictors of successful antipsychotic
dose reduction in schizophrenia. Prospective clinical trials and randomized controlled trials …

Antipsychotic polypharmacy refers to the co-prescription of more than one antipsychotic drug
for an individual patient. Surveys of prescribing in psychiatric services internationally have …