[HTML][HTML] Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
S Raghavan, PS Winter, AW Navia, HL Williams… - Cell, 2021 - cell.com
Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
J Peng, BF Sun, CY Chen, JY Zhou, YS Chen, H Chen… - Cell research, 2019 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …
featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively …
Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single-cell transcriptomics in real-world pancreatic cancer biopsies
Purpose: Precision medicine approaches in pancreatic ductal adenocarcinoma (PDAC) are
imperative for improving disease outcomes. With molecular subtypes of PDAC gaining …
imperative for improving disease outcomes. With molecular subtypes of PDAC gaining …
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis
S Zhang, W Fang, S Zhou, D Zhu, R Chen… - Nature …, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all
targeted and immune therapies. However, our understanding of PDAC microenvironment …
targeted and immune therapies. However, our understanding of PDAC microenvironment …
Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways
Background The majority of pancreatic ductal adenocarcinomas (PDAC) are diagnosed at
the metastatic stage, and standard therapies have limited activity with a dismal 5-year …
the metastatic stage, and standard therapies have limited activity with a dismal 5-year …
Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment
G Werba, D Weissinger, EA Kawaler, E Zhao… - Nature …, 2023 - nature.com
The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a
complex ecosystem that drives tumor progression; however, in-depth single cell …
complex ecosystem that drives tumor progression; however, in-depth single cell …
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
Single-cell analysis of patient-derived PDAC organoids reveals cell state heterogeneity and a conserved developmental hierarchy
TG Krieger, S Le Blanc, J Jabs, FW Ten… - Nature …, 2021 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is projected to be the second leading cause of
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …
cancer mortality by 2030. Bulk transcriptomic analyses have distinguished 'classical'from …
[HTML][HTML] Spatially confined sub-tumor microenvironments in pancreatic cancer
Intratumoral heterogeneity is a critical frontier in understanding how the tumor
microenvironment (TME) propels malignant progression. Here, we deconvolute the human …
microenvironment (TME) propels malignant progression. Here, we deconvolute the human …
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal and treatment-refractory
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …
cancer. Molecular stratification in pancreatic cancer remains rudimentary and does not yet …