Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron

S Wang, H Sun, Y Zhang, L Yuan, Y Wang, T Zhang… - Cell reports, 2022 - cell.com
The rapidly spreading Omicron variant is highly resistant to vaccines, convalescent sera,
and neutralizing antibodies (nAbs), highlighting the urgent need for potent therapeutic nAbs …

Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants

S Changrob, PJ Halfmann, H Liu… - The Journal of …, 2023 - Am Soc Clin Investig
The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron variants has emphasized the need to identify antibodies with broad neutralizing …

A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues

C Yi, Z Ling, X Lu, Y Fu, Z Yang, S Wangmo… - Cellular & Molecular …, 2022 - nature.com
The newly emerged Omicron (B. 1.1. 529) variant of SARS-CoV-2 is quickly overtaking the
Delta variant and becoming the dominant strain around the world due to its enhanced …

Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence

KM Hastie, X Yu, F Ana-Sosa-Batiz, DS Zyla… - Cell Reports, 2023 - cell.com
Therapeutic antibodies are an important tool in the arsenal against coronavirus infection.
However, most antibodies developed early in the pandemic have lost most or all efficacy …

Broadly neutralizing antibodies against Omicron-included SARS-CoV-2 variants induced by vaccination

X Chi, Y Guo, G Zhang, H Sun, J Zhang, M Li… - Signal transduction and …, 2022 - nature.com
Abstract The SARS-CoV-2 Omicron variant shows substantial resistance to neutralization by
infection-and vaccination-induced antibodies, highlighting the demands for research on the …

Potent antibodies against immune invasive SARS-CoV-2 Omicron subvariants

L Wang, Y Wang, H Zhou - International Journal of Biological …, 2023 - Elsevier
The development of neutralizing antibodies (nAbs) is an important strategy to tackle the
Omicron variant. Omicron N-terminal domain (NTD) mutations including A67V, G142D, and …

[HTML][HTML] Potent Monoclonal antibodies neutralize Omicron Sublineages and other SARS-Cov-2 variants

Z Chen, P Zhang, Y Matsuoka, Y Tsybovsky, K West… - Cell Reports, 2022 - cell.com
The emergence and global spread of the SARS-CoV-2 Omicron variants, which carry an
unprecedented number of mutations, raise serious concerns due to the reduced efficacy of …

Broadly neutralizing human antibodies against Omicron subvariants of SARS-CoV-2

HL Chiang, KH Liang, RM Lu, TW Kuo, YL Lin… - Journal of Biomedical …, 2023 - Springer
Background The COVID-19 pandemic continues to pose a significant worldwide threat to
human health, as emerging SARS-CoV-2 Omicron variants exhibit resistance to therapeutic …

Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron …

X Li, Y Pan, Q Yin, Z Wang, S Shan, L Zhang, J Yu… - Cell discovery, 2022 - nature.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern
(VOCs), especially the latest Omicron, have exhibited severe antibody evasion. Broadly …

The neutralizing breadth of antibodies targeting diverse conserved epitopes between SARS-CoV and SARS-CoV-2

H Xiong, H Sun, S Wang, L Yuan… - Proceedings of the …, 2022 - National Acad Sciences
Antibody therapeutics for the treatment of COVID-19 have been highly successful. However,
the recent emergence of the Omicron variant has posed a challenge, as it evades detection …