Following the Ebola virus disease epidemic in west Africa, there has been increased
awareness of the need for improved therapies for emerging diseases, including viral …

Ebola Virus Disease (EVD) is one of the most lethal transmissible infections, characterized
by a high fatality rate, and caused by a member of the Filoviridae family. The recent large …

Opinion statement Purpose of review Ebola virus, a member of the Filoviridae family, is a
causative agent of severe viral hemorrhagic fever in humans. Over the past 40 years, the …

Currently, no approved therapeutics exist to treat or prevent infections induced by Ebola
viruses, and recent events have demonstrated an urgent need for rapid discovery of new …

In light of the current outbreak of Ebola virus disease, there is an urgent need to develop
effective therapeutics to treat Ebola infection, and drug repurposing screening is a …

The filoviruses—Ebola virus and Marburg virus—cause lethal haemorrhagic fever in
humans and non-human primates (NHPs). Filoviruses present a global health threat both as …

Background. The high case-fatality rate during the recent Ebola virus (EBOV) outbreak in
West Africa is due in part to the lack of effective antiviral therapies. Antiviral screening …

Specific host pathways that may be targeted therapeutically to inhibit the replication of Ebola
virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 …

Highlights•Ebola virus infection causes fulminant hemorrhagic fevers in humans with high
lethality rates.•No approved treatment for ebola virus infection exists.•Antiviral research …

Ebola virus (EBOV) causes severe hemorrhagic fever, for which therapeutic options are not
available. Preventing the entry of EBOV into host cells is an attractive antiviral strategy …