The efficiency of antigen (A g) processing by dendritic cells (DC s) is vital for the strength of
the ensuing T‐cell responses. Previously, we and others have shown that in comparison to …

There is now a consensus that efficient peptide vaccination against cancer requires that
peptides should (i) be exclusively presented by professional APC and (ii) stimulate both …

Dendritic cells (DCs) effectively process exogenous and endogenous Ag and present
peptide in the context of both class I and class II molecules. We have demonstrated that …

Antitumor vaccination using synthetic long peptides (SLP) is an additional therapeutic
strategy currently under development. It aims to activate tumor-specific CD8+ CTL by …

Presentation of exogenous antigens on MHC class I molecules, termed cross-presentation,
is essential for the induction of CD8 T-cell responses and is carried out by specialized …

In dendritic cells (DCs), peptides derived from internalized particulate substrates are
efficiently cross-presented by major histocompatibility complex (MHC) class I molecules …

In antigen presentation to CD4+ T cells, proteins are degraded to peptide fragments and
loaded onto class II MHC molecules in a process involving the peptide exchange factors H …

Exosomes are secreted vesicles formed in late endocytic compartments. Mature dendritic
cells (DCs) secrete exosomes bearing functional MHC-peptide complexes and high levels of …

Synthetic peptide vaccines aiming at the induction of a protective CD8+ T-cell response
against infectious or malignant diseases are widely used in the clinic but, despite their …

Dendritic cells (DCs) are crucial for priming of naive CD8+ T lymphocytes to exogenous
antigens, so-called “cross-priming.” We report that exogenous protein antigen can be …