CCR5/CXCR3 antagonist TAK-779 prevents diffuse alveolar damage of the lung in the murine model of the acute respiratory distress syndrome

AS Chernov, MV Rodionov, VA Kazakov… - Frontiers in …, 2024 - frontiersin.org
Introduction: The acute respiratory distress syndrome (ARDS), secondary to viral
pneumonitis, is one of the main causes of high mortality in patients with COVID-19 (novel …

CCR5/CXCR3 antagonist TAK-779 prevents diffuse alveolar damage of the lung in murine model of the SARS-CoV-2-related acute respiratory distress syndrome

A Chernov, M Rodionov, V Kazakov, K Ivanova… - bioRxiv, 2023 - biorxiv.org
The acute respiratory distress syndrome (ARDS) secondary to viral pneumonitis is one of the
main causes of high mortality in patients with COVID-19 (novel coronavirus disease 2019) …

Pharmacological modulation of C‐X‐C motif chemokine receptor 4 influences development of acute respiratory distress syndrome after lung ischaemia–reperfusion …

SP Nassoiy, FS Babu, HM LaPorte… - Clinical and …, 2018 - Wiley Online Library
Summary Activation of C‐X‐C motif chemokine receptor 4 (CXCR4) has been reported to
result in lung protective effects in various experimental models. The effects of …

Beneficial effects of CCL8 inhibition at lipopolysaccharide-induced lung injury

A Naderi, E Farmaki, B Chavez, C Cai, V Kaza… - Iscience, 2022 - cell.com
Summary CCL8 (MCP-2) is a chemoattractive cytokine associated with various immune-
related pathologies. Recent studies show that CCL8 is significantly stimulated during acute …

Natural and engineered chemokine (CXC motif) receptor 4 agonists prevent acute respiratory distress syndrome after lung ischemia–reperfusion injury and …

FS Babu, X Liang, GA Enten, AJ DeSantis… - Scientific Reports, 2020 - nature.com
We compared therapeutic properties of natural and engineered chemokine (CXC motif)
receptor 4 (CXCR4) agonists in a rat acute respiratory distress syndrome (ARDS) model …

CXCR7 antagonism reduces acute lung injury pathogenesis

L Pouzol, A Sassi, N Baumlin, M Tunis… - Frontiers in …, 2021 - frontiersin.org
Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the
pathogenesis of life-threatening acute lung injury (ALI) and its more severe form, acute …

Absence of CCR2 promotes proliferation of alveolar macrophages that control lung inflammation in acute respiratory distress syndrome in mice

VLS Oliveira, E Pollenus, N Berghmans… - International Journal of …, 2022 - mdpi.com
Acute respiratory distress syndrome (ARDS) consists of uncontrolled inflammation that
causes hypoxemia and reduced lung compliance. Since it is a complex process, not all …

CCR2: A potential target for lung injury resolution

AF Villabona-Rueda, Q Zhong, Y Xiong, T Palmer… - 2020 - Eur Respiratory Soc
Introduction: Alveolar macrophages helps in maintaining the homeostasis in the lungs.
CCL2 and its receptor CCR2 play a role regulating the monocyte and leukocyte trafficking …

[HTML][HTML] CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

BK Patterson, H Seethamraju, K Dhody… - International Journal of …, 2021 - Elsevier
Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is
now a global pandemic. Emerging results indicate a dysregulated immune response. Given …

[PDF][PDF] Therapeutic inhibition of CXC chemokine receptor 2 by SB225002 attenuates LPS-induced acute lung injury in mice

Q Cao, B Li, X Wang, K Sun, Y Guo - Archives of Medical Science, 2018 - termedia.pl
Results Histology findings revealed that the SB225002-treated group had significantly
milder lung injury compared to the LPS-induced ALI and the PBS-treated control groups …