Rheumatoid arthritis pathogenesis, prediction, and prevention: an emerging paradigm shift

KD Deane, VM Holers - Arthritis & Rheumatology, 2021 - Wiley Online Library
Rheumatoid arthritis (RA) is currently diagnosed and treated when an individual presents
with signs and symptoms of inflammatory arthritis (IA) as well as other features, such as …

Preclinical rheumatoid arthritis and rheumatoid arthritis prevention

HK Greenblatt, HA Kim, LF Bettner… - Current opinion in …, 2020 - journals.lww.com
The results from ongoing natural history and prevention trials in RA should further inform
several critical issues in RA prevention including identification and enrolment of individuals …

The pre-clinical phase of rheumatoid arthritis: from risk factors to prevention of arthritis

N Petrovská, K Prajzlerová, J Vencovský, L Šenolt… - Autoimmunity …, 2021 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease considered as a multistep
process spanning from the interaction of genetic (eg, shared epitope or non-HLA loci) …

[HTML][HTML] Prevention of rheumatoid arthritis: a systematic literature review of preventive strategies in at-risk individuals

G Frazzei, A Musters, N de Vries, SW Tas… - Autoimmunity …, 2023 - Elsevier
Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by
symmetrical peripheral polyarthritis in the hands and/or feet, leading to long-term disability if …

EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis

K Mankia, HJ Siddle, A Kerschbaumer… - Annals of the …, 2021 - ard.bmj.com
Background Despite growing interest, there is no guidance or consensus on how to conduct
clinical trials and observational studies in populations at risk of rheumatoid arthritis (RA) …

Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review

VC Romão, JE Fonseca - Frontiers in medicine, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Preventing progression from arthralgia to arthritis: targeting the right patients

HW Van Steenbergen, JAP Da Silva… - Nature Reviews …, 2018 - nature.com
Early treatment is associated with improved outcomes in patients with rheumatoid arthritis
(RA), suggesting that a'window of opportunity', in which the disease is most susceptible to …

Update on the epidemiology, risk factors, and disease outcomes of rheumatoid arthritis

D van der Woude, AHM van der Helm-van - Best practice & research …, 2018 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation,
which affects approximately 1% of the population. The benefit of early recognition and …

[PDF][PDF] The preclinical phase of rheumatoid arthritis: what is acknowledged and what needs to be assessed

HW Van Steenbergen, TW Huizinga… - Arthritis …, 2013 - scholarlypublications …
Rheumatoid arthritis (RA) affects 1% of the population worldwide and is characterised by
persistent inflammation and joint damage. It has repeatedly been observed that early …

Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE

KD Deane, H El-Gabalawy - Nature Reviews Rheumatology, 2014 - nature.com
Established and emerging data demonstrate that a'preclinical'period of disease precedes
the onset of clinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as …